A simple, accurate, sensitive and rapid second order derivative UV spectroscopic method for simultaneous estimation of both the drug in synthetic mixture. In this method detection was carried out at 292 nm (ZCP of naltrexone hydrochloride) and 240. nm (ZCP of pentazocine hydrochloride). The UV spectroscopic method for naltrexone hydrochloride and pentazocine hydrochloride was found to be linear over the range of 5-9 μg/ml and 500-900 μg/ml respectively for the second derivative method. Correlation coefficient for naltrexone hydrochloride and pentazocine hydrochloride was found to be 0.998 and 0.998 respectively. Accuracy (% recovery) for naltrexone hydrochloride and pentazocine hydrochloride was 98.00% - 99.40% and 98.70% - 99.24% respectively.
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